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Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.
Agudelo, Leandro Z; Ferreira, Duarte M S; Dadvar, Shamim; Cervenka, Igor; Ketscher, Lars; Izadi, Manizheh; Zhengye, Liu; Furrer, Regula; Handschin, Christoph; Venckunas, Tomas; Brazaitis, Marius; Kamandulis, Sigitas; Lanner, Johanna T; Ruas, Jorge L.
  • Agudelo LZ; Department of Physiology and Pharmacology, Molecular and Cellular Exercise Physiology, Karolinska Institutet, Biomedicum C5, 171 77, Stockholm, Sweden.
  • Ferreira DMS; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Dadvar S; Department of Physiology and Pharmacology, Molecular and Cellular Exercise Physiology, Karolinska Institutet, Biomedicum C5, 171 77, Stockholm, Sweden.
  • Cervenka I; Department of Physiology and Pharmacology, Molecular and Cellular Exercise Physiology, Karolinska Institutet, Biomedicum C5, 171 77, Stockholm, Sweden.
  • Ketscher L; Department of Physiology and Pharmacology, Molecular and Cellular Exercise Physiology, Karolinska Institutet, Biomedicum C5, 171 77, Stockholm, Sweden.
  • Izadi M; Department of Physiology and Pharmacology, Molecular and Cellular Exercise Physiology, Karolinska Institutet, Biomedicum C5, 171 77, Stockholm, Sweden.
  • Zhengye L; Department of Physiology and Pharmacology, Molecular and Cellular Exercise Physiology, Karolinska Institutet, Biomedicum C5, 171 77, Stockholm, Sweden.
  • Furrer R; Department of Physiology and Pharmacology, Molecular Muscle Physiology and Pathophysiology, Karolinska Institutet, Biomedicum C5, 171 77, Stockholm, Sweden.
  • Handschin C; Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056, Basel, Switzerland.
  • Venckunas T; Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056, Basel, Switzerland.
  • Brazaitis M; Institute of Sports Science and Innovations, Lithuanian Sports University, Sporto str. 6, 44221, Kaunas, Lithuania.
  • Kamandulis S; Institute of Sports Science and Innovations, Lithuanian Sports University, Sporto str. 6, 44221, Kaunas, Lithuania.
  • Lanner JT; Institute of Sports Science and Innovations, Lithuanian Sports University, Sporto str. 6, 44221, Kaunas, Lithuania.
  • Ruas JL; Department of Physiology and Pharmacology, Molecular Muscle Physiology and Pathophysiology, Karolinska Institutet, Biomedicum C5, 171 77, Stockholm, Sweden.
Nat Commun ; 10(1): 2767, 2019 06 24.
Article en En | MEDLINE | ID: mdl-31235694
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Músculo Esquelético / Metabolismo Energético / Fatiga / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Quinurenina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Músculo Esquelético / Metabolismo Energético / Fatiga / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Quinurenina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article