TREM2 function impedes tau seeding in neuritic plaques.

Leyns, Cheryl E G; Gratuze, Maud; Narasimhan, Sneha; Jain, Nimansha; Koscal, Lauren J; Jiang, Hong; Manis, Melissa; Colonna, Marco; Lee, Virginia M Y; Ulrich, Jason D; Holtzman, David M

Leyns, Cheryl E G; Gratuze, Maud; Narasimhan, Sneha; Jain, Nimansha; Koscal, Lauren J; Jiang, Hong; Manis, Melissa; Colonna, Marco; Lee, Virginia M Y; Ulrich, Jason D; Holtzman, David M.

Leyns CEG; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Gratuze M; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
Narasimhan S; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Jain N; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Koscal LJ; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
Jiang H; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Manis M; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Colonna M; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Lee VMY; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
Ulrich JD; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Nat Neurosci ; 22(8): 1217-1222, 2019 08.

Article en En | MEDLINE | ID: mdl-31235932

Asunto(s)

Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/metabolismo; Placa Amiloide/genética; Placa Amiloide/metabolismo; Receptores Inmunológicos/genética; Receptores Inmunológicos/metabolismo; Tauopatías/genética; Tauopatías/metabolismo; Proteínas tau/genética; Proteínas tau/metabolismo; Animales; Corteza Cerebral/patología; Ratones; Ratones Noqueados; Microglía/patología

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Receptores Inmunológicos / Proteínas tau / Placa Amiloide / Tauopatías Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article

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