Cardiodynamic Interactions between Two S1P<sub>1</sub> Receptor Modulators in an Experimental Clinical Setting: Different Pharmacokinetic Properties as an Opportunity to Mitigate First-Dose Heart Rate Effects.

Juif, Pierre-Eric; Ufer, Mike; Dingemanse, Jasper

Cardiodynamic Interactions between Two S1P₁ Receptor Modulators in an Experimental Clinical Setting: Different Pharmacokinetic Properties as an Opportunity to Mitigate First-Dose Heart Rate Effects.

Juif, Pierre-Eric; Ufer, Mike; Dingemanse, Jasper.

Juif PE; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil CH-4123, Switzerland. pierre-eric.juif@idorsia.com.
Ufer M; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil CH-4123, Switzerland.
Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil CH-4123, Switzerland.

Int J Mol Sci ; 20(13)2019 Jul 01.

Article en En | MEDLINE | ID: mdl-31266149

Asunto(s)

Frecuencia Cardíaca/efectos de los fármacos; Moduladores de los Receptores de fosfatos y esfingosina 1/administración & dosificación; Receptores de Esfingosina-1-Fosfato/agonistas; Tiazoles/administración & dosificación; Adulto; Método Doble Ciego; Electrocardiografía Ambulatoria; Femenino; Semivida; Voluntarios Sanos; Humanos; Recuento de Linfocitos; Masculino; Distribución Aleatoria; Moduladores de los Receptores de fosfatos y esfingosina 1/farmacocinética; Tiazoles/farmacocinética; Adulto Joven

Palabras clave

S1P1 receptor modulators; first-dose effect; pharmacokinetics

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiazoles / Moduladores de los Receptores de fosfatos y esfingosina 1 / Receptores de Esfingosina-1-Fosfato / Frecuencia Cardíaca Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male Idioma: En Año: 2019 Tipo del documento: Article

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