Validation of the triple timed up-and-go test in Lambert-Eaton myasthenia.
Muscle Nerve
; 60(3): 292-298, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31269226
ABSTRACT
INTRODUCTION:
There are no validated, practical, and quantitative measures of disease severity in Lambert-Eaton myasthenia (LEM).METHODS:
Data from the Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome (DAPPER) trial were analyzed to assess triple timed up-and-go (3TUG) reproducibility and relationships between 3TUG times and other measures of LEM severity.RESULTS:
The coverage probability technique showed ≥0.90 probability for an acceptable 3TUG difference of ≤0.2, indicating that it is reproducible in LEM patients. The correlation between 3TUG times and lower extremity function scores was significant in subjects who continued and in those who were withdrawn from 3,4-diaminopyridine free base. Worsening patient-reported Weakness Self-Assessment Scale and Investigator Assessment of Treatment Effect scores corresponded with prolongation of 3TUG times.DISCUSSION:
The 3TUG is reproducible, demonstrates construct validity for assessment of lower extremity function in LEM patients, and correlates with changes in patient and physician assessments. These findings, along with prior reliability studies, indicate 3TUG is a valid measure of disease severity in LEM.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Síndrome Miasténico de Lambert-Eaton
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Debilidad Muscular
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Extremidad Inferior
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article