DNA interaction and photodynamic antitumor activity of transition metal mono-hydroxyl corrole.
Bioorg Chem
; 90: 103085, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31279233
ABSTRACT
A series of iron(III), manganese(III) and copper(III) mono-hydroxyl corrole complexes had been prepared and well characterized by UV-vis, 1H NMR, 19F NMR and HR-MS. These metallocorroles may bind to CT-DNA through external binding mode. Metallocorrole Fe-2c exhibited significant phototoxicity and low toxicity toward A549 tumor cells. While manganese (III) and copper (III) corroles showed hypotoxicity to A549, MCF-7 and HepG-2 tumor cells, whether under dark or illumination conditions. All tested metallocorroles exhibited non-toxicity to human normal cells (GES-1) with or without irradiation at 625â¯nm. Cell cycle analysis indicated that metallocorrole Fe-2c arrested the cell cycle at G2/M phase and increased the Sub-G1 phase in A549 cell lines. It was mainly localized at mitochondria and could significantly reduce mitochondrial membrane potential after photodynamic treatment, which would further induce tumor cell apoptosis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Porfirinas
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ADN
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Compuestos Férricos
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Cobre
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Manganeso
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Neoplasias
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Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article