Autoimmune response and its long-term consequences after exon-skipping therapy in a Duchenne muscular dystrophy mouse model.
J Pathol
; 249(3): 271-273, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31322741
ABSTRACT
The progress of antisense-based therapies using first generation Morpholino oligonucleotides for Duchenne muscular dystrophy (DMD) is expected to partially restore dystrophin expression and may prolong the lifespan of DMD patients. In a recent issue of The Journal of Pathology, a sophisticated study by Vila et al used a dystrophic mouse model of DMD to demonstrate that Morpholino-induced exon skipping induced dystrophin expression in skeletal muscle and stimulated cell mediated and humoral responses to dystrophin. The study highlights the need to further investigate the autoimmune response against de novo synthesised truncated dystrophin protein and its long-term consequences after exon-skipping therapy for DMD. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Distrofina
/
Distrofia Muscular de Duchenne
Límite:
Animals
/
Humans
País como asunto:
Europa
Idioma:
En
Año:
2019
Tipo del documento:
Article