Mogrol attenuates lipopolysaccharide (LPS)-induced memory impairment and neuroinflammatory responses in mice.
J Asian Nat Prod Res
; 22(9): 864-878, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-31347387
ABSTRACT
This study aimed to evaluate whether mogrol, a main bioactive ingredient of Siraitia grosvenorii, could attenuate LPS-induced memory impairment in mice. The behavioral tests and immunohistochemical analysis and Western blot were performed. The present results showed that oral administration of mogrol (20, 40, 80 mg/kg) significantly improved LPS-induced memory impairment in mice. The results also indicated that mogrol treatment significantly reduced the number of Iba1-positive cells, the nuclear NF-κB p65 and levels of TNF-α, IL-1ß and IL-6 both in the hippocampus and frontal cortex of LPS-challenged mice. [Formula see text].
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Banco de datos:
MEDLINE
Asunto principal:
Lipopolisacáridos
/
Inflamación
Límite:
Animals
Idioma:
En
Año:
2020
Tipo del documento:
Article