Genetic diversity of HLA system in two populations from Tabasco, Mexico: Villahermosa and rural Tabasco.
Hum Immunol
; 81(9): 560-562, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-31350050
ABSTRACT
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (Nâ¯=â¯82) and rural communities (Nâ¯=â¯142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Tabasco include 13 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Tabasco are Native American (67.79⯱â¯1.59% by ML; 56.25% of Native American haplotypes) and European (27.21⯱â¯3.97% by ML; 29.91% of European haplotypes), and a less prominent African genetic component (5.01⯱â¯4.42% by ML; 8.93% of African haplotypes).
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Etnicidad
/
Genética de Población
/
Antígenos HLA
Límite:
Humans
País como asunto:
Mexico
Idioma:
En
Año:
2020
Tipo del documento:
Article