Conjugate vaccines dramatically reshaped the epidemiology of bacterial meningitis in a well-defined child population.
Acta Paediatr
; 109(2): 368-374, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31365152
ABSTRACT
AIM:
We explored the impact of vaccination on bacterial meningitis in a well-defined population of children on the island of Crete, Greece, over a 27-y period.METHODS:
This was a retrospective observational study of all mandatory notifications of bacterial meningitis in patients aged 1 mo-14 y from 1991 to 2017.RESULTS:
There were 245 patients with proven (n = 227) or suspected (n = 18) bacterial meningitis, and eight deaths were recorded, giving a case fatality rate of 3.3%. The mean annual incidence rate (IR) per 100 000 children was 4.9 for Neisseria meningitidis, 2.2 for Streptococcus pneumoniae and 0.4 for Haemophilus influenzae type b (Hib). Cases of meningitis C dropped significantly after the conjugate meningitis C vaccine was licensed for routine vaccination in Greece in 2000 (IR of 1.5 vs 0.3, P < 0.028) while the Streptococcus pneumoniae cases showed a threefold decrease after the PCV13 vaccine was licensed in Greece in 2009 (IR 2.7 vs 1.0, P < 0.03). Vaccination had already eliminated Hib in Greece in the 1990s.CONCLUSION:
Bacterial meningitis cases decreased in children following the introduction of the meningitis C and PCV13 vaccines in Greece. Hib had already disappeared and significant reductions in meningitis C and Streptococcus pneumoniae were observed.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Meningitis Bacterianas
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Haemophilus influenzae tipo b
Tipo de estudio:
Incidence_studies
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Observational_studies
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Prognostic_studies
/
Screening_studies
Límite:
Child
/
Humans
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Infant
País como asunto:
Europa
Idioma:
En
Año:
2020
Tipo del documento:
Article