Botulinum toxin-induced ADP-ribosylation and inhibition of exocytosis are unrelated events.
FEBS Lett
; 238(2): 277-80, 1988 Oct 10.
Article
en En
| MEDLINE
| ID: mdl-3139458
ABSTRACT
The hypothesis that inhibition of secretion by botulinum neurotoxin type D occurs by an intracellular process involving ADP-ribosylation has been directly tested by measuring both the extent of inhibition of secretion and of ADP-ribosylation in the same cells. Although the inhibitory effect of unpurified toxin closely parallels intracellular ribosylation, the two events are clearly unrelated, as using purified D and C3 toxins together with their antibodies, each of these events can be either stimulated or inhibited independently of each other.
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Banco de datos:
MEDLINE
Asunto principal:
Toxinas Botulínicas
/
Catecolaminas
/
Adenosina Difosfato Ribosa
/
Sistema Cromafín
/
Médula Suprarrenal
/
Exocitosis
Límite:
Animals
Idioma:
En
Año:
1988
Tipo del documento:
Article