Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data.
BMC Neurol
; 19(1): 190, 2019 Aug 09.
Article
en En
| MEDLINE
| ID: mdl-31399069
ABSTRACT
BACKGROUND:
Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. CASE PRESENTATION Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS.CONCLUSIONS:
In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Leucoencefalopatía Multifocal Progresiva
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Síndrome Inflamatorio de Reconstitución Inmune
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Clorhidrato de Fingolimod
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Inmunosupresores
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
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Humans
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Male
Idioma:
En
Año:
2019
Tipo del documento:
Article