The ghrelin <i>O</i>-acyltransferase structure reveals a catalytic channel for transmembrane hormone acylation.

Campaña, Maria B; Irudayanathan, Flaviyan Jerome; Davis, Tasha R; McGovern-Gooch, Kayleigh R; Loftus, Rosemary; Ashkar, Mohammad; Escoffery, Najae; Navarro, Melissa; Sieburg, Michelle A; Nangia, Shikha; Hougland, James L

The ghrelin O-acyltransferase structure reveals a catalytic channel for transmembrane hormone acylation.

Campaña, Maria B; Irudayanathan, Flaviyan Jerome; Davis, Tasha R; McGovern-Gooch, Kayleigh R; Loftus, Rosemary; Ashkar, Mohammad; Escoffery, Najae; Navarro, Melissa; Sieburg, Michelle A; Nangia, Shikha; Hougland, James L.

Campaña MB; Department of Chemistry, Syracuse University, Syracuse, New York 13244.
Irudayanathan FJ; Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13244.
Davis TR; Department of Chemistry, Syracuse University, Syracuse, New York 13244.
McGovern-Gooch KR; Department of Chemistry, Syracuse University, Syracuse, New York 13244.
Loftus R; Department of Chemistry, Syracuse University, Syracuse, New York 13244.
Ashkar M; Department of Chemistry, Syracuse University, Syracuse, New York 13244.
Escoffery N; Department of Chemistry, Syracuse University, Syracuse, New York 13244.
Navarro M; Department of Chemistry, Syracuse University, Syracuse, New York 13244.
Sieburg MA; Department of Chemistry, Syracuse University, Syracuse, New York 13244.
Nangia S; Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13244 snangia@syr.edu.
Hougland JL; Syracuse Biomaterials Institute, Syracuse University, Syracuse, New York 13244.

J Biol Chem ; 294(39): 14166-14174, 2019 09 27.

Article en En | MEDLINE | ID: mdl-31413115

Asunto(s)

Aciltransferasas/química; Dominio Catalítico; Acetilación; Aciltransferasas/metabolismo; Animales; Ghrelina/química; Ghrelina/metabolismo; Humanos; Células Sf9; Spodoptera

Palabras clave

acyltransferase; co-evolutionary constraint; computational modeling; ghrelin O-acyltransferase (GOAT); integral membrane protein; membrane enzyme; membrane protein; membrane-bound O-acyltransferase (MBOAT); post-translational modification (PTM); protein acylation; protein structure; protein structure prediction; structural biology

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aciltransferasas / Dominio Catalítico Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google