Synthesis of Tetrahydro[1,3,4]triazepines via Redox-Neutral α-C(sp3)-H Amination of Cyclic Amines.
J Org Chem
; 84(18): 11839-11847, 2019 Sep 20.
Article
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| MEDLINE
| ID: mdl-31433189
ABSTRACT
A Brønsted acid-catalyzed α-C(sp3)-H amination of cyclic amines using hydrazines as coupling partners has been reported. This methodology provides a unique protocol to the one-step assembly of tetrahydro[1,3,4]triazepines via [1,5]-hydride transfer-initiated C(sp3)-H amination. This reaction features mild conditions, good yields, and high atom economy.
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2019
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Article