Age at menopause and lung function: a Mendelian randomisation study.
Eur Respir J
; 54(4)2019 10.
Article
en En
| MEDLINE
| ID: mdl-31439684
ABSTRACT
In observational studies, early menopause is associated with lower forced vital capacity (FVC) and a higher risk of spirometric restriction, but not airflow obstruction. It is, however, unclear if this association is causal. We therefore used a Mendelian randomisation (MR) approach, which is not affected by classical confounding, to assess the effect of age at natural menopause on lung function.We included 94â742 naturally post-menopausal women from the UK Biobank and performed MR analyses on the effect of age at menopause on forced expiratory volume in 1â
s (FEV1), FVC, FEV1/FVC, spirometric restriction (FVC
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Menopausia Prematura
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Pulmón
Tipo de estudio:
Clinical_trials
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Observational_studies
Límite:
Aged
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Female
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Humans
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Middle aged
Idioma:
En
Año:
2019
Tipo del documento:
Article