Disrupted Habituation in the Early Stage of Psychosis.
Biol Psychiatry Cogn Neurosci Neuroimaging
; 4(11): 1004-1012, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31445881
ABSTRACT
BACKGROUND:
Learning and memory are impaired in schizophrenia. Some theories have proposed that one form of memory, habituation, is particularly impaired. Preliminary evidence suggests that memory impairment is associated with failed hippocampal habituation in patients with chronic schizophrenia. We studied how abnormal habituation of the hippocampus is related to relational memory deficits in the early stage of psychosis.METHODS:
We measured hippocampal activity in 62 patients with early psychosis and 70 healthy individuals using functional magnetic resonance imaging. Habituation was defined as the slope of functional magnetic resonance imaging signal change to repeated presentations of faces and objects. Relational memory ability was measured as the slope of preferential viewing during a face-scene pair eye movement task outside the scanner.RESULTS:
Patients with early psychosis showed impaired relational memory (p < .001) and less hippocampal habituation to objects (p = .01) than healthy control subjects. In the healthy control group, better relational memory was associated with faster anterior hippocampal habituation (faces, r = -.28, p = .03). In contrast, patients with early psychosis showed no brain-behavior relationship (r = .12, p = .40).CONCLUSIONS:
We found evidence for disrupted hippocampal habituation in the early stage of psychosis along with an altered association between hippocampal habituation and relational memory ability. These results suggest that neural habituation may provide a novel target for early cognitive interventions in psychosis.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Reconocimiento Visual de Modelos
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Trastornos Psicóticos
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Esquizofrenia
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Corteza Visual
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Habituación Psicofisiológica
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Hipocampo
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Trastornos de la Memoria
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2019
Tipo del documento:
Article