Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879).
Mar Drugs
; 17(9)2019 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-31480497
ABSTRACT
An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1-3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Terpenos
/
Antozoos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article