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A substantial proportion of apparently heterozygous TP53 pathogenic variants detected with a next-generation sequencing hereditary pan-cancer panel are acquired somatically.
Coffee, Bradford; Cox, Hannah C; Bernhisel, Ryan; Manley, Susan; Bowles, Karla; Roa, Benjamin B; Mancini-DiNardo, Debora.
  • Coffee B; Myriad Genetic Laboratories, Inc., Salt Lake City, Utah.
  • Cox HC; Myriad Genetic Laboratories, Inc., Salt Lake City, Utah.
  • Bernhisel R; Myriad Genetic Laboratories, Inc., Salt Lake City, Utah.
  • Manley S; Myriad Genetic Laboratories, Inc., Salt Lake City, Utah.
  • Bowles K; Myriad Genetic Laboratories, Inc., Salt Lake City, Utah.
  • Roa BB; Myriad Genetic Laboratories, Inc., Salt Lake City, Utah.
  • Mancini-DiNardo D; Myriad Genetic Laboratories, Inc., Salt Lake City, Utah.
Hum Mutat ; 41(1): 203-211, 2020 01.
Article en En | MEDLINE | ID: mdl-31490007
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Predisposición Genética a la Enfermedad / Estudios de Asociación Genética / Heterocigoto / Mutación / Neoplasias Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Predisposición Genética a la Enfermedad / Estudios de Asociación Genética / Heterocigoto / Mutación / Neoplasias Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article