Determinants of utilization of cryopreservation of germ cells in adolescent cancer patients in four European countries.
Eur J Pediatr
; 179(1): 51-60, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-31493021
ABSTRACT
Infertility is a relevant late-effect following cancer treatment; yet, a large proportion of survivors cannot recall having been informed of this risk. In an intervention study, we examined if and how supportive patient information material on fertility/fertility-preserving measures influences utilization of cryopreservation in adolescent cancer patients. The control group, recruited 03/2014-01/2016, received the usual patient education at initial diagnosis. The intervention group, recruited 04/2016-10/2017, received patient education supported by a fertility flyer and brochure. Patients and parents were each asked questions on utilization of cryopreservation in a questionnaire 3 and 6 months after initial diagnosis. Patient core and therapy data were obtained from medical records. Overall, cryopreservation rates showed no significant difference between the control (32.7%, n = 37/113) and intervention group (36.6%, n = 37/101). In the control group, cryopreservation was associated with gender (OR 0.100, CI 0.023-0.427), age (OR 1.559, CI 1.077-2.258) and recalling information on fertility protection (OR 33.663, CI 2.100-539.574); in the intervention group, cryopreservation was related to gender (OR 0.093, CI 0.026-0.330) and the estimated infertility risk (OR 43.665, CI 2.157-883.974).Conclusion:
Cryopreservation rates did not overall increase following the intervention; however, the individual risk seemed to be brought into attention more Those at risk, including younger patients, cryopreserved at higher rates.What is Knownâ¢Infertility is a relevant late-effect following adolescent cancer.â¢Guidelines recommend to offer fertility protection before cancer treatment.â¢A relevant proportion of adolescents with cancer are not aware of this risk.â¢Fertility protection seems under-used in cancer patients at risk for infertility.What is Newâ¢Information material on fertility and protection in adolescents did not increase overall rates of cryopreservation.â¢Cryopreservation rates were improved according to individual risk for infertility.â¢Our flyers and brochures on fertility in cancer patients are available in various languages.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aceptación de la Atención de Salud
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Criopreservación
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Educación del Paciente como Asunto
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Preservación de la Fertilidad
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Células Germinativas
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Neoplasias
Tipo de estudio:
Etiology_studies
/
Guideline
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Observational_studies
/
Prognostic_studies
/
Qualitative_research
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
País como asunto:
Europa
Idioma:
En
Año:
2020
Tipo del documento:
Article