Glymphatics Visualization after Focused Ultrasound-Induced Blood-Brain Barrier Opening in Humans.
Ann Neurol
; 86(6): 975-980, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31525269
ABSTRACT
It is currently unclear whether the glymphatic system, a brain-wide interstitial fluid-cerebrospinal fluid exchange described in rodents, exists in humans. Focal blood-brain barrier disruption using magnetic resonance-guided focused ultrasound allows parenchymal penetration of gadobutrol contrast, creating an opportunity to study glymphatics in vivo noninvasively. We describe patterns of contrast distribution in the perivascular space, subarachnoid space, and space surrounding large veins draining toward the dural sinuses on fluid-attenuated inversion recovery in subjects with Alzheimer disease and amyotrophic lateral sclerosis. This is the first evidence suggesting glymphatic efflux persists in humans. It's relevance to proteinopathies and drug delivery is discussed. ANN NEUROL 2019;86975-980.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
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Barrera Hematoencefálica
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Ultrasonografía Intervencional
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Enfermedad de Alzheimer
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Sistema Glinfático
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Esclerosis Amiotrófica Lateral
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2019
Tipo del documento:
Article