Surviving Telomere Attrition with the MiDAS Touch.
Trends Genet
; 35(11): 783-785, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31526614
ABSTRACT
Cancer cells maintain telomere lengths through telomerase activity or by alternative lengthening of telomeres (ALT). Using an engineered model system, a recent study by Min et al. reveals that the combination of BLM-mediated DNA resection and telomere clustering, a characteristic of ALT telomeres, catalyzes RAD52-dependent mitotic DNA synthesis (MiDAS) specifically at telomeres to drive ALT activity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Telómero
/
Telomerasa
Tipo de estudio:
Prognostic_studies
Idioma:
En
Año:
2019
Tipo del documento:
Article