Immunomodulatory Functions of the Human Cathelicidin LL-37 (aa 13-31)-Derived Peptides are Associated with Predicted &#945;-Helical Propensity and Hydrophobic Index.

Hemshekhar, Mahadevappa; Faiyaz, Sana; Choi, Ka-Yee Grace; Krokhin, Oleg V; Mookherjee, Neeloffer

Immunomodulatory Functions of the Human Cathelicidin LL-37 (aa 13-31)-Derived Peptides are Associated with Predicted α-Helical Propensity and Hydrophobic Index.

Hemshekhar, Mahadevappa; Faiyaz, Sana; Choi, Ka-Yee Grace; Krokhin, Oleg V; Mookherjee, Neeloffer.

Hemshekhar M; Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E3P4, Canada. Hem.Mahadevappa@umanitoba.ca.
Faiyaz S; Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E3P4, Canada. sanafaiyaz@gmail.com.
Choi KG; Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E3P4, Canada. grace@hancocklab.com.
Krokhin OV; Department of Immunology, University of Manitoba, Winnipeg, MB R3E 3P4, Canada. grace@hancocklab.com.
Mookherjee N; Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E3P4, Canada. Oleg.Krokhine@umanitoba.ca.

Biomolecules ; 9(9)2019 09 18.

Article en En | MEDLINE | ID: mdl-31540479

Asunto(s)

Antiinflamatorios/farmacología; Péptidos Catiónicos Antimicrobianos/química; Lipopolisacáridos/efectos adversos; Péptidos/farmacología; Antiinflamatorios/química; Simulación por Computador; Citocinas/metabolismo; Regulación hacia Abajo; Regulación de la Expresión Génica/efectos de los fármacos; Humanos; Interacciones Hidrofóbicas e Hidrofílicas; Proteína Antagonista del Receptor de Interleucina 1/metabolismo; Leucocitos Mononucleares/efectos de los fármacos; Leucocitos Mononucleares/inmunología; Macrófagos/efectos de los fármacos; Macrófagos/inmunología; Péptidos/química; Conformación Proteica en Hélice alfa; Células THP-1; Catelicidinas

Palabras clave

IG-19; LL-37; cathelicidin; hydrophobicity; immunomodulation; inflammation; peptide retention time; α-helicity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos / Lipopolisacáridos / Péptidos Catiónicos Antimicrobianos / Antiinflamatorios Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article

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