Higher fasting ghrelin serum levels in active smokers than in former and never-smokers.
World J Biol Psychiatry
; 21(10): 748-756, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-31552785
ABSTRACT
OBJECTIVES:
Ghrelin, an orexigenic peptide hormone, promotes drug reward and is suspected to play a role in nicotine dependence. However, there is little data on whether ghrelin levels are associated with active and/or former smoking. The relationship between ghrelin serum levels and smoking status in a population-based sample of individuals was studied.METHODS:
Total ghrelin was determined after an overnight fast in 1519 subjects participating in a population-based cohort study ('LIFE-Adult'). Tobacco consumption was assessed using both the questionnaire and interview. Generalised linear models with gamma distribution and log-link function were performed to analyse the association of total serum ghrelin with smoking status and the association between serum ghrelin and the amount of tobacco consumed in active smokers.RESULTS:
Ghrelin levels were positively associated with active, but not former smoking (OR = 1.095; p = .002). This association was not moderated by sex (interaction of 'active smoking' and sex p = .346). Ghrelin levels were not associated with the amount of tobacco consumed in active smokers.CONCLUSIONS:
This study provides evidence that total ghrelin serum levels are positively associated with active smoking. No association was found for former smokers. A unique feature of the study is the large sample size.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ayuno
/
Ghrelina
/
Fumadores
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article