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A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery.
Chakravarty, Shatadru; Sarma, Saurav J; Goswami, Lalit N; Cai, Quan-Yu; Shapiro, Erik M; Hawthorne, M Frederick; Ma, Lixin.
  • Chakravarty S; International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, MO 65212, USA. mal@health.missouri.edu and Molecular and Cellular Imaging Laboratory, Department of Radiology, Michigan State University, East Lansing, MI 48823, USA and Institute fo
  • Sarma SJ; International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, MO 65212, USA. mal@health.missouri.edu and Bond Life Sciences Centre, University of Missouri, Columbia, MO 65201, USA and MU Metabolomics Centre, University of Missouri, Columbia, MO
  • Goswami LN; International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, MO 65212, USA. mal@health.missouri.edu.
  • Cai QY; International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, MO 65212, USA. mal@health.missouri.edu and Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA.
  • Shapiro EM; Molecular and Cellular Imaging Laboratory, Department of Radiology, Michigan State University, East Lansing, MI 48823, USA and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48823, USA.
  • Hawthorne MF; International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, MO 65212, USA. mal@health.missouri.edu.
  • Ma L; International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, MO 65212, USA. mal@health.missouri.edu and Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA.
Chem Commun (Camb) ; 55(82): 12348-12351, 2019 Oct 10.
Article en En | MEDLINE | ID: mdl-31559401
ABSTRACT
A multimeric MRI contrast agent based on the closo-borane motif is reported. Twelve copies of a modified AAZTA chelate with an alkyne end group are appended on an azide-functionalized closo-borane motif using Cu(i) catalyzed click chemistry. The presence of two water molecules on the Gd-bound AAZTA chelate results in high relaxivity for the closomer in vitro/in vivo.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Azepinas / Boranos / Imagen por Resonancia Magnética / Quelantes / Medios de Contraste / Complejos de Coordinación / Acetatos Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Azepinas / Boranos / Imagen por Resonancia Magnética / Quelantes / Medios de Contraste / Complejos de Coordinación / Acetatos Idioma: En Año: 2019 Tipo del documento: Article