A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery.
Chem Commun (Camb)
; 55(82): 12348-12351, 2019 Oct 10.
Article
en En
| MEDLINE
| ID: mdl-31559401
ABSTRACT
A multimeric MRI contrast agent based on the closo-borane motif is reported. Twelve copies of a modified AAZTA chelate with an alkyne end group are appended on an azide-functionalized closo-borane motif using Cu(i) catalyzed click chemistry. The presence of two water molecules on the Gd-bound AAZTA chelate results in high relaxivity for the closomer in vitro/in vivo.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Azepinas
/
Boranos
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Imagen por Resonancia Magnética
/
Quelantes
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Medios de Contraste
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Complejos de Coordinación
/
Acetatos
Idioma:
En
Año:
2019
Tipo del documento:
Article