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Influence of Pain and Analgesia on Orthopedic and Wound-healing Models in Rats and Mice.
Huss, Monika K; Felt, Stephen A; Pacharinsak, Cholawat.
  • Huss MK; Department of Comparative Medicine, Stanford University, Stanford, California;, Email: monikag@stanford.edu.
  • Felt SA; Department of Comparative Medicine, Stanford University, Stanford, California.
  • Pacharinsak C; Department of Comparative Medicine, Stanford University, Stanford, California.
Comp Med ; 69(6): 535-545, 2019 12 01.
Article en En | MEDLINE | ID: mdl-31561753
ABSTRACT
The surgical stress response and resulting physiologic changes can lead to postoperative complications and negatively impact animal welfare. Although appropriate pain management is crucial to reduce the pain and stress response to surgery, analgesic choice can significantly affect bone and wound healing. This review aims to summarize data from rat and mouse studies and to provide recommendations for integrating analgesia into orthopedic and wound healing models in these species. Data from other species, such as humans, rabbits and other rodents, is included, where available. From these data, we conclude that for orthopedic surgical models, opioids, local anesthetics and dissociative agents have minimal impact on fracture healing; cyclooxygenase 2 (COX2) selective nonsteroidal antiinflammatory drugs (NSAID) may be used in the shortterm; and steroids should be avoided. For wound healing models, short-term systemic or topical opioids have negligible impact on wound healing; NSAID or local anesthetics may be used short-term; and systemic steroids should be avoided. Alternative analgesics such as tramadol, gabapentin, ketamine, and acetaminophen warrant consideration and further evaluation for both orthopedic and wound healing models. In all cases, researchers and veterinarians should work together to determine the appropriate analgesic plan to minimize pain, as well as to minimize unwanted effects on the orthopedic and wound healing models themselves.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ratas / Estrés Fisiológico / Cicatrización de Heridas / Manejo del Dolor / Ratones Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ratas / Estrés Fisiológico / Cicatrización de Heridas / Manejo del Dolor / Ratones Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article