Recombinant Human Interleukin-15 and Anti-PD-L1 Combination Therapy Expands a CXCR3+PD1-/low CD8 T-Cell Subset in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

Chen, Ping; Chen, Hui; Moussa, Maha; Cheng, Jie; Li, Tong; Qin, Jing; Lifson, Jeffrey D; Sneller, Michael C; Krymskaya, Ludmila; Godin, Steven; Lane, H Clifford; Catalfamo, Marta

Chen, Ping; Chen, Hui; Moussa, Maha; Cheng, Jie; Li, Tong; Qin, Jing; Lifson, Jeffrey D; Sneller, Michael C; Krymskaya, Ludmila; Godin, Steven; Lane, H Clifford; Catalfamo, Marta.

Chen P; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Chen H; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Moussa M; CMRS/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Cheng J; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Li T; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Qin J; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Lifson JD; Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Sneller MC; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland, USA.
Krymskaya L; CMRS/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Godin S; Clinical Support Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
Lane HC; Smithers Avanza Toxicology Services, Gaithersburg, Maryland, USA.
Catalfamo M; CMRS/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

J Infect Dis ; 221(4): 523-533, 2020 02 03.

Article en En | MEDLINE | ID: mdl-31562760

Asunto(s)

Anticuerpos Monoclonales Humanizados/farmacología; Anticuerpos Monoclonales Humanizados/uso terapéutico; Antígeno B7-H1/antagonistas & inhibidores; Linfocitos T CD8-positivos/inmunología; Interleucina-15/uso terapéutico; Receptor de Muerte Celular Programada 1/metabolismo; Receptores CXCR3/metabolismo; Síndrome de Inmunodeficiencia Adquirida del Simio/tratamiento farmacológico; Virus de la Inmunodeficiencia de los Simios; Animales; Anticuerpos Monoclonales Humanizados/efectos adversos; Quimioterapia Combinada; Femenino; Humanos; Interleucina-15/efectos adversos; Interleucina-15/genética; Macaca mulatta; Masculino; Proteínas Recombinantes/efectos adversos; Proteínas Recombinantes/uso terapéutico; Síndrome de Inmunodeficiencia Adquirida del Simio/inmunología; Síndrome de Inmunodeficiencia Adquirida del Simio/virología; Resultado del Tratamiento; Carga Viral/efectos de los fármacos

Palabras clave

HIV/SIV infection; IL-15; anti-PD-L1; checkpoint inhibitor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome de Inmunodeficiencia Adquirida del Simio / Virus de la Inmunodeficiencia de los Simios / Linfocitos T CD8-positivos / Interleucina-15 / Receptores CXCR3 / Anticuerpos Monoclonales Humanizados / Antígeno B7-H1 / Receptor de Muerte Celular Programada 1 Límite: Animals / Female / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article

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