The impact of preoperative biliary stenting in pancreatic cancer: A case-matched study from the German nationwide pancreatic surgery registry (DGAV StuDoQ|Pancreas).
Pancreatology
; 19(7): 985-993, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-31563328
ABSTRACT
BACKGROUND/OBJECTIVE:
The impact of preoperative biliary stenting (PBS) before pancreatoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) is controversial.METHODS:
Patients undergoing PD with or without PBS for PDAC were identified from the German DGAV-StuDoQlPancreas registry. The impact of PBS on perioperative complications was analyzed.RESULTS:
1133 patients undergoing PD for PDAC were identified from the registry. After matching, 480 PBS patients vs. 480 patients without PBS were analyzed. Postoperative complications Clavien-Dindo classification (CDC) grade IIIa-IVb were higher in PBS patients (PBS 27% vs. no PBS 22%, pâ¯=â¯0.027). 320 PBS patients (66%) had no history of jaundice. In these patients, PBS was associated with higher morbidity. In contrast, PBS was not associated with higher complication rates in patients with history of jaundice. Serum bilirubin levels of 15â¯mg/dl and higher lead to more CDC IIIa-IVb (24% vs. 28%, pâ¯=â¯0.053) and higher mortality (3% vs. 7%, pâ¯<â¯0.001). PBS in patients with serum bilirubin levels of >15â¯mg/dl increased CDC IIa-IVb complications (21% vs. 50%, pâ¯=â¯0.001), mortality was equivalent.CONCLUSION:
Most PBS procedures were performed in patients with no history of jaundice and increased morbidity. Serum bilirubin levels >15â¯mg/dl lead to higher morbidity and mortality. PBS correlated with higher complication rates in these patients.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Procedimientos Quirúrgicos del Sistema Biliar
/
Stents
/
Sistema de Registros
/
Pancreaticoduodenectomía
/
Carcinoma Ductal Pancreático
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
País como asunto:
Europa
Idioma:
En
Año:
2019
Tipo del documento:
Article