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Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin.
Veniaminova, Natalia A; Grachtchouk, Marina; Doane, Owen J; Peterson, Jamie K; Quigley, David A; Lull, Madison V; Pyrozhenko, Daryna V; Nair, Raji R; Patrick, Matthew T; Balmain, Allan; Dlugosz, Andrzej A; Tsoi, Lam C; Wong, Sunny Y.
  • Veniaminova NA; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Grachtchouk M; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Doane OJ; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Peterson JK; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Quigley DA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Lull MV; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Pyrozhenko DV; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Nair RR; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Patrick MT; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine & Bioinformatics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Balmain A; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Dlugosz AA; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Tsoi LC; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine & Bioinformatics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Wong SY; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: sunnyw@umich.edu.
Dev Cell ; 51(3): 326-340.e4, 2019 11 04.
Article en En | MEDLINE | ID: mdl-31564613
Oil-secreting sebaceous glands (SGs) are critical for proper skin function; however, it remains unclear how different factors act together to modulate SG stem cells. Here, we provide functional evidence that each SG lobe is serviced by its own dedicated stem cell population. Upon ablating Notch signaling in different skin subcompartments, we find that this pathway exerts dual counteracting effects on SGs. Suppressing Notch in SG progenitors traps them in a hybrid state where stem and differentiation features become intermingled. In contrast, ablating Notch outside of the SG stem cell compartment indirectly drives SG expansion. Finally, we report that a K14:K5→K14:K79 keratin shift occurs during SG differentiation. Deleting K79 destabilizes K14 in sebocytes, and attenuates SGs and eyelid meibomian glands, leading to corneal ulceration. Altogether, our findings demonstrate that SGs integrate diverse signals from different niches and suggest that mutations incurred within one stem cell compartment can indirectly influence another.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glándulas Sebáceas / Piel / Células Madre / Nicho de Células Madre Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glándulas Sebáceas / Piel / Células Madre / Nicho de Células Madre Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article