The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function.

Oberbeck, Nina; Pham, Victoria C; Webster, Joshua D; Reja, Rohit; Huang, Christine S; Zhang, Yue; Roose-Girma, Merone; Warming, Søren; Li, Qingling; Birnberg, Andrew; Wong, Weng; Sandoval, Wendy; Komuves, László G; Yu, Kebing; Dugger, Debra L; Maltzman, Allie; Newton, Kim; Dixit, Vishva M

Oberbeck, Nina; Pham, Victoria C; Webster, Joshua D; Reja, Rohit; Huang, Christine S; Zhang, Yue; Roose-Girma, Merone; Warming, Søren; Li, Qingling; Birnberg, Andrew; Wong, Weng; Sandoval, Wendy; Komuves, László G; Yu, Kebing; Dugger, Debra L; Maltzman, Allie; Newton, Kim; Dixit, Vishva M.

Oberbeck N; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Pham VC; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
Webster JD; Department of Pathology, Genentech, South San Francisco, CA, USA.
Reja R; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA, USA.
Huang CS; Department of Protein Chemistry, Genentech, South San Francisco, CA, USA.
Zhang Y; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA, USA.
Roose-Girma M; Department of Molecular Biology, Genentech, South San Francisco, CA, USA.
Warming S; Department of Molecular Biology, Genentech, South San Francisco, CA, USA.
Li Q; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
Birnberg A; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
Wong W; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
Sandoval W; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
Komuves LG; Department of Pathology, Genentech, South San Francisco, CA, USA.
Yu K; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
Dugger DL; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Maltzman A; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Newton K; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Dixit VM; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. dixit@gene.com.

Nature ; 574(7777): 249-253, 2019 10.

Article en En | MEDLINE | ID: mdl-31578523

Asunto(s)

Diferenciación Celular; Células Epidérmicas/citología; Epidermis/fisiología; Factores Reguladores del Interferón/metabolismo; Proteínas Serina-Treonina Quinasas/metabolismo; Transducción de Señal; Anomalías Múltiples/genética; Animales; Labio Leporino/genética; Fisura del Paladar/genética; Quistes/genética; Embrión de Mamíferos/citología; Embrión de Mamíferos/embriología; Embrión de Mamíferos/metabolismo; Células Epidérmicas/metabolismo; Epidermis/embriología; Anomalías del Ojo/genética; Femenino; Dedos/anomalías; Regulación de la Expresión Génica; Factores Reguladores del Interferón/deficiencia; Factores Reguladores del Interferón/genética; Rodilla/anomalías; Articulación de la Rodilla/anomalías; Labio/anomalías; Metabolismo de los Lípidos/genética; Deformidades Congénitas de las Extremidades Inferiores/genética; Masculino; Ratones; Ratones Endogámicos C57BL; Fosforilación; Fosfoserina/metabolismo; Proteínas Serina-Treonina Quinasas/genética; Sindactilia/genética; Anomalías Urogenitales/genética

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Diferenciación Celular / Proteínas Serina-Treonina Quinasas / Epidermis / Factores Reguladores del Interferón / Células Epidérmicas Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article

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