Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs.
Nucleosides Nucleotides Nucleic Acids
; 39(5): 671-687, 2020.
Article
en En
| MEDLINE
| ID: mdl-31588837
ABSTRACT
Novel 7-trifluoromethyl-7-deazapurine ribonucleoside analogs (13a-c) and their Protides (15a-c) were successfully synthesized from ribolactol or 1-α-bromo-ribose derivatives using Silyl-Hilbert-Johnson or nucleobase-anion substitution reactions followed by key aromatic trifluoromethyl substitution. Newly prepared compounds were evaluated against a panel of RNA viruses, including HCV, Ebola or Zika viruses.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Purinas
/
Ribonucleósidos
/
Profármacos
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article