Mechanisms of gallium-67 accumulation by tumors: role of cell membrane permeability.
J Nucl Med
; 29(5): 663-8, 1988 May.
Article
en En
| MEDLINE
| ID: mdl-3163725
ABSTRACT
The effects of citrate ion on in vitro and in vivo uptake of [67Ga]citrate by tumor cells have been studied. Carrier-free [67Ga]citrate seems to follow the physical diffusion of citrate ions into the cell, and the presence of carrier gallium inhibits that diffusion, reducing considerably its uptake. These results appear to support the hypothesis that increased permeability of tumor cells is the principal cause of [67Ga]citrate accumulation by tumors.
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Banco de datos:
MEDLINE
Asunto principal:
Células Tumorales Cultivadas
/
Permeabilidad de la Membrana Celular
/
Radioisótopos de Galio
Límite:
Animals
Idioma:
En
Año:
1988
Tipo del documento:
Article