The Route from the Folded to the Amyloid State: Exploring the Potential Energy Surface of a Drug-Like Miniprotein.

Taricska, Nóra; Horváth, Dániel; Menyhárd, Dóra K; Ákontz-Kiss, Hanna; Noji, Masahiro; So, Masatomo; Goto, Yuji; Fujiwara, Toshimichi; Perczel, András

Taricska, Nóra; Horváth, Dániel; Menyhárd, Dóra K; Ákontz-Kiss, Hanna; Noji, Masahiro; So, Masatomo; Goto, Yuji; Fujiwara, Toshimichi; Perczel, András.

Taricska N; Laboratory of Structural Chemistry and Biology &, MTA-ELTE Protein Modeling Research Group, Eötvös Loránd University, Pázmány Péter sétány 1A, 1117, Budapest, Hungary.
Horváth D; Laboratory of Structural Chemistry and Biology &, MTA-ELTE Protein Modeling Research Group, Eötvös Loránd University, Pázmány Péter sétány 1A, 1117, Budapest, Hungary.
Menyhárd DK; Laboratory of Structural Chemistry and Biology &, MTA-ELTE Protein Modeling Research Group, Eötvös Loránd University, Pázmány Péter sétány 1A, 1117, Budapest, Hungary.
Ákontz-Kiss H; Laboratory of Structural Chemistry and Biology &, MTA-ELTE Protein Modeling Research Group, Eötvös Loránd University, Pázmány Péter sétány 1A, 1117, Budapest, Hungary.
Noji M; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
So M; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Goto Y; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Fujiwara T; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Perczel A; Laboratory of Structural Chemistry and Biology &, MTA-ELTE Protein Modeling Research Group, Eötvös Loránd University, Pázmány Péter sétány 1A, 1117, Budapest, Hungary.

Chemistry ; 26(9): 1968-1978, 2020 Feb 11.

Article en En | MEDLINE | ID: mdl-31647140

Asunto(s)

Amiloide/metabolismo; Secuencia de Aminoácidos; Amiloide/química; Dicroismo Circular; Concentración de Iones de Hidrógeno; Simulación de Dinámica Molecular; Resonancia Magnética Nuclear Biomolecular; Péptidos/química; Conformación Proteica; Pliegue de Proteína; Temperatura

Palabras clave

aggregation; amyloid beta-peptides; protein folding; protein modeling

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