The Hedgehog Signaling Pathway in Ischemic Tissues.
Int J Mol Sci
; 20(21)2019 Oct 24.
Article
en En
| MEDLINE
| ID: mdl-31652910
ABSTRACT
Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in the ischemic condition is also presented.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Proteínas Hedgehog
/
Isquemia
Límite:
Animals
/
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article