Polysaccharides obtained from mycelia of Cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy.
Afr Health Sci
; 19(2): 2156-2163, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-31656500
ABSTRACT
OBJECTIVES:
Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy.METHODS:
Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells.RESULTS:
PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells.CONCLUSION:
These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polisacáridos
/
Doxorrubicina
/
Cordyceps
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article