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An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma.
Wen, Chen-Lei; Huang, Ke; Jiang, Lu-Lu; Lu, Xiong-Xiong; Dai, Yu-Ting; Shi, Min-Min; Tang, Xiao-Mei; Wang, Qing-Bing; Zhang, Xiao-Dan; Wang, Peng-Hui; Li, Hui-Ti; Ruan, Xiao-Xue; Wang, Li-Wen; Wang, Xin-Jing; Wang, Qian; Lu, Wei; Xiang, Xiao-Qiang; Sun, Xun; Xu, Yan-Hui; Lai, Lu-Hua; Zhan, Qian; Li, Hong-Wei; Peng, Cheng-Hong; Chen, Jing; Huang, Jin-Yan; Ye, De-Yong; Chen, Sai-Juan; Chen, Zhu; Li, Min; Fang, Yuan; Shen, Bai-Yong; Zhou, Lu.
  • Wen CL; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Huang K; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Jiang LL; School of Pharmacy, Fudan University, 201203 Shanghai, China.
  • Lu XX; School of Pharmacy, Fudan University, 201203 Shanghai, China.
  • Dai YT; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Shi MM; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Tang XM; National Research Center for Translational Medicine, Ruijin Hospital, 200025 Shanghai, China.
  • Wang QB; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Zhang XD; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240 Shanghai, China.
  • Wang PH; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Li HT; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Ruan XX; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Wang LW; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Wang XJ; Department of Interventional Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Wang Q; School of Pharmacy, Fudan University, 201203 Shanghai, China.
  • Lu W; School of Pharmacy, Fudan University, 201203 Shanghai, China.
  • Xiang XQ; School of Pharmacy, Fudan University, 201203 Shanghai, China.
  • Sun X; School of Pharmacy, Fudan University, 201203 Shanghai, China.
  • Xu YH; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Lai LH; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Zhan Q; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Li HW; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Peng CH; Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University, 200032 Shanghai, China.
  • Chen J; School of Pharmacy, Fudan University, 201203 Shanghai, China.
  • Huang JY; School of Pharmacy, Fudan University, 201203 Shanghai, China.
  • Ye DY; School of Pharmacy, Fudan University, 201203 Shanghai, China.
  • Chen SJ; Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University, 200032 Shanghai, China.
  • Chen Z; College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China.
  • Li M; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Fang Y; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Shen BY; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
  • Zhou L; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China.
Proc Natl Acad Sci U S A ; 116(46): 23264-23273, 2019 11 12.
Article en En | MEDLINE | ID: mdl-31662475
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Fosfoglicerato Mutasa / Carcinoma Ductal Pancreático / Antineoplásicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Fosfoglicerato Mutasa / Carcinoma Ductal Pancreático / Antineoplásicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article