Tumor Immunosurveillance and Immunotherapies: A Fresh Look from Intravital Imaging.
Trends Immunol
; 40(11): 1022-1034, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31668676
ABSTRACT
Understanding complex interactions between the immune system and the tumor microenvironment is an essential step towards the rational development and optimization of immunotherapies. Several experimental approaches are available to tackle this complexity but most are not designed to address the dynamic features of immune reactions, including cell migration, cellular interactions, and transient signaling events. By providing a unique means to access these precious parameters, intravital imaging offers a fresh look at intratumoral immune responses at the single-cell level. Here, we discuss how in vivo imaging sheds light on fundamental aspects of tumor immunity and helps elucidate modes of action of immunotherapies. We conclude by discussing future developments that may consolidate the unique contribution of intravital imaging for our understanding of tumor immunity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Microscopía Intravital
/
Inmunoterapia
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article