Spatially-enhanced time-domain NIRS for accurate determination of tissue optical properties.
Opt Express
; 27(19): 26415-26431, 2019 Sep 16.
Article
en En
| MEDLINE
| ID: mdl-31674524
ABSTRACT
A multivariate method integrating time and space resolved techniques of near-infrared spectroscopy is proposed for simultaneously retrieving the absolute quantities of optical absorption and scattering properties in tissues. The time-domain feature of photon migration is advantageously constrained and regularized by its spatially-resolved amplitude patterns in the inverse procedure. Measurements of tissue-mimicking phantoms with various optical properties are analyzed with Monte-Carlo simulations to validate the method performance. The uniqueness, stability, and uncertainty of the method are discussed.
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2019
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Article