Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism.

Cortazar, Michael A; Sheridan, Ryan M; Erickson, Benjamin; Fong, Nova; Glover-Cutter, Kira; Brannan, Kristopher; Bentley, David L

Cortazar, Michael A; Sheridan, Ryan M; Erickson, Benjamin; Fong, Nova; Glover-Cutter, Kira; Brannan, Kristopher; Bentley, David L.

Cortazar MA; RNA Bioscience Initiative, Department Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Sheridan RM; RNA Bioscience Initiative, Department Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Erickson B; RNA Bioscience Initiative, Department Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Fong N; RNA Bioscience Initiative, Department Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Glover-Cutter K; RNA Bioscience Initiative, Department Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Brannan K; RNA Bioscience Initiative, Department Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Bentley DL; RNA Bioscience Initiative, Department Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA. Electronic address: david.bentley@cuanschutz.edu.

Mol Cell ; 76(6): 896-908.e4, 2019 12 19.

Article en En | MEDLINE | ID: mdl-31677974

Asunto(s)

Proteínas de Unión al ADN/metabolismo; Exorribonucleasas/metabolismo; Proteína Fosfatasa 1/metabolismo; Procesamiento Proteico-Postraduccional; ARN Polimerasa II/metabolismo; ARN Mensajero/biosíntesis; Proteínas de Unión al ARN/metabolismo; Terminación de la Transcripción Genética; Sitios de Unión; Proteínas de Unión al ADN/genética; Exorribonucleasas/genética; Células HEK293; Humanos; Cinética; Proteínas Nucleares/genética; Fosforilación; Poli A/metabolismo; Unión Proteica; Proteína Fosfatasa 1/genética; ARN Mensajero/genética; Proteínas de Unión al ARN/genética; Transducción de Señal; Factores de Elongación Transcripcional/genética

Palabras clave

PNUTS; PP1 phosphatase; Pol II elongation rate; Spt5 phosphorylation; transcription termination

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ARN Polimerasa II / ARN Mensajero / Procesamiento Proteico-Postraduccional / Proteínas de Unión al ARN / Proteínas de Unión al ADN / Exorribonucleasas / Proteína Fosfatasa 1 / Terminación de la Transcripción Genética Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article

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