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Abilities of ß-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells.
Akula, Shaw M; Candido, Saverio; Abrams, Stephen L; Steelman, Linda S; Lertpiriyapong, Kvin; Cocco, Lucio; Ramazzotti, Giulia; Ratti, Stefano; Follo, Matilde Y; Martelli, Alberto M; Murata, Ramiro M; Rosalen, Pedro L; Bueno-Silva, Bruno; Matias de Alencar, Severino; Falasca, Marco; Montalto, Giuseppe; Cervello, Melchiorre; Notarbartolo, Monica; Gizak, Agnieszka; Rakus, Dariusz; Libra, Massimo; McCubrey, James A.
  • Akula SM; Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA.
  • Candido S; Department of Biomedical and Biotechnological Sciences, Oncological, Clinical and General Pathology Section, University of Catania, Catania, Italy; Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy.
  • Abrams SL; Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA.
  • Steelman LS; Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA.
  • Lertpiriyapong K; Center of Comparative Medicine and Pathology, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medicine and the Hospital for Special Surgery, New York City, New York, USA.
  • Cocco L; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
  • Ramazzotti G; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
  • Ratti S; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
  • Follo MY; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
  • Martelli AM; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
  • Murata RM; Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA; Department of Foundational Sciences, School of Dental Medicine, East Carolina University, USA.
  • Rosalen PL; Department of Physiological Sciences, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil.
  • Bueno-Silva B; Department of Physiological Sciences, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil; Dental Research Division, Guarulhos University, Guarulhos, Brazil.
  • Matias de Alencar S; Universidade de São Paulo - USP, "Luiz de Queiroz" College of Agriculture, São Paulo, Brazil.
  • Falasca M; Metabolic Signalling Group, School of Pharmacy & Biomedical Sciences, Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Perth, Western Australia, 6102, Australia.
  • Montalto G; Dipartimento di Promozione Della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy; Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy.
  • Cervello M; Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy.
  • Notarbartolo M; Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy.
  • Gizak A; Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland.
  • Rakus D; Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland.
  • Libra M; Department of Biomedical and Biotechnological Sciences, Oncological, Clinical and General Pathology Section, University of Catania, Catania, Italy; Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy.
  • McCubrey JA; Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA. Electronic address: mccubreyj@ecu.edu.
Adv Biol Regul ; 75: 100672, 2020 01.
Article en En | MEDLINE | ID: mdl-31685431
Improving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhance the effectiveness of chemotherapy. For example, signal transduction inhibitors or hormonal based approaches have been included with chemo- or radio-therapy. MIA-PaCa-2 and BxPC-3 pancreatic ductal adenocarcinoma (PDAC) cells both express the estrogen receptor (ER). The effects of ß-estradiol on the growth of PDAC cells has not been examined yet the ER is expressed in PDAC cells. We have examined the effects of combining ß-estradiol with chemotherapeutic drugs, signal transcription inhibitors, natural products and nutraceuticals on PDAC. In most cases, inclusion of ß-estradiol with chemotherapeutic drugs increased chemosensitivity. These results indicate some approaches involving ß-estradiol which may be used to increase the effectiveness of chemotherapeutic and other drugs on the growth of PDAC.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Transducción de Señal / Suplementos Dietéticos / Carcinoma Ductal Pancreático / Proliferación Celular / Estradiol / Antineoplásicos Límite: Female / Humans / Middle aged Idioma: En Año: 2020 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Transducción de Señal / Suplementos Dietéticos / Carcinoma Ductal Pancreático / Proliferación Celular / Estradiol / Antineoplásicos Límite: Female / Humans / Middle aged Idioma: En Año: 2020 Tipo del documento: Article