Serelaxin inhibits the profibrotic TGF-ß1/IL-1ß axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts.

Cáceres, Felipe Tapia; Gaspari, Tracey A; Samuel, Chrishan S; Pinar, Anita A

Cáceres, Felipe Tapia; Gaspari, Tracey A; Samuel, Chrishan S; Pinar, Anita A.

Cáceres FT; Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
Gaspari TA; Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
Samuel CS; Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
Pinar AA; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria, Australia.

FASEB J ; 33(12): 14717-14733, 2019 12.

Article en En | MEDLINE | ID: mdl-31689135

Asunto(s)

Miocardio/metabolismo; Miofibroblastos/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Relaxina/farmacología; Receptor Toll-Like 4/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo; Animales; Células Cultivadas; Fibrosis; Humanos; Inflamasomas/metabolismo; Interleucina-1beta/metabolismo; Masculino; Ratones; Miocardio/citología; Miocardio/patología; Miofibroblastos/efectos de los fármacos; Proteínas Recombinantes/farmacología

Palabras clave

IL-1 ß serelaxin; RXFP1; cardiac fibrosis; cardiomyopathy; nNOS

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Relaxina / Receptor Toll-Like 4 / Factor de Crecimiento Transformador beta1 / Miofibroblastos / Proteína con Dominio Pirina 3 de la Familia NLR / Miocardio Límite: Animals / Humans / Male Idioma: En Año: 2019 Tipo del documento: Article

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