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Pure tone audiometry and cerebral pathology in healthy older adults.
Parker, Thomas; Cash, David M; Lane, Chris; Lu, Kirsty; Malone, Ian B; Nicholas, Jennifer M; James, Sarah; Keshavan, Ashvini; Murray-Smith, Heidi; Wong, Andrew; Buchannan, Sarah; Keuss, Sarah; Sudre, Carole H; Thomas, David; Crutch, Sebastian; Bamiou, Doris-Eva; Warren, Jason D; Fox, Nick C; Richards, Marcus; Schott, Jonathan M.
  • Parker T; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Cash DM; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Lane C; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Lu K; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Malone IB; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Nicholas JM; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • James S; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
  • Keshavan A; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Murray-Smith H; MRC Unit for Lifelong Health and Ageing at UCL, UCL, London, UK.
  • Wong A; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Buchannan S; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Keuss S; MRC Unit for Lifelong Health and Ageing at UCL, UCL, London, UK.
  • Sudre CH; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Thomas D; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Crutch S; KCL School of Biomedical Engineering and Imaging Sciences, London, UK.
  • Bamiou DE; Neuradiological Academic Unit, UCL, London, Greater London, UK.
  • Warren JD; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Fox NC; UCL Ear Institute and UCLH Biomedical Research Centre, National Institute for Health Research, UCL, London, UK.
  • Richards M; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Schott JM; The Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
J Neurol Neurosurg Psychiatry ; 91(2): 172-176, 2020 02.
Article en En | MEDLINE | ID: mdl-31699832
ABSTRACT

BACKGROUND:

Hearing impairment may be a modifiable risk factor for dementia. However, it is unclear how hearing associates with pathologies relevant to dementia in preclinical populations.

METHODS:

Data from 368 cognitively healthy individuals born during 1 week in 1946 (age range 69.2-71.9 years), who underwent structural MRI, 18F-florbetapir positron emission tomography, pure tone audiometry and cognitive testing as part of a neuroscience substudy the MRC National Survey of Health and Development were analysed. The aim of the analysis was to investigate whether pure tone audiometry performance predicted a range of cognitive and imaging outcomes relevant to dementia in older adults.

RESULTS:

There was some evidence that poorer pure tone audiometry performance was associated with lower primary auditory cortex thickness, but no evidence that it predicted in vivo ß-amyloid deposition, white matter hyperintensity volume, hippocampal volume or Alzheimer's disease-pattern cortical thickness. A negative association between pure tone audiometry and mini-mental state examination score was observed, but this was no longer evident after excluding a test item assessing repetition of a single phrase.

CONCLUSION:

Pure tone audiometry performance did not predict concurrent ß-amyloid deposition, small vessel disease or Alzheimer's disease-pattern neurodegeneration, and had limited impact on cognitive function, in healthy adults aged approximately 70 years.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Audiometría de Tonos Puros / Encéfalo / Valor Predictivo de las Pruebas / Demencia Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Audiometría de Tonos Puros / Encéfalo / Valor Predictivo de las Pruebas / Demencia Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article