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Prevalence, Biotransformation, and Maternal Transfer of Synthetic Phenolic Antioxidants in Pregnant Women from South China.
Du, Bibai; Zhang, Yun; Lam, James C W; Pan, Shilei; Huang, Yuxin; Chen, Baowei; Lan, Shenyu; Li, Juan; Luo, Dan; Zeng, Lixi.
  • Du B; Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment , Jinan University , Guangzhou 511443 , China.
  • Zhang Y; Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment , Jinan University , Guangzhou 511443 , China.
  • Lam JCW; Department of Science and Environmental Studies , The Education University of Hong Kong , Hong Kong SAR , China.
  • Pan S; Department of Obstetrics and Gynecology , Zhujiang Hospital of Southern Medical University , Guangzhou 510280 , China.
  • Huang Y; Department of Obstetrics and Gynecology , Zhujiang Hospital of Southern Medical University , Guangzhou 510280 , China.
  • Chen B; Southern Marine Science and Engineering Guangdong Laboratory, School of Marine Sciences , Sun Yat-sen University , Zhuhai 519082 , China.
  • Lan S; Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment , Jinan University , Guangzhou 511443 , China.
  • Li J; Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment , Jinan University , Guangzhou 511443 , China.
  • Luo D; Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment , Jinan University , Guangzhou 511443 , China.
  • Zeng L; Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment , Jinan University , Guangzhou 511443 , China.
Environ Sci Technol ; 53(23): 13959-13969, 2019 Dec 03.
Article en En | MEDLINE | ID: mdl-31702911
Synthetic phenolic antioxidants (SPAs) have been identified as an emerging group of contaminants in recent years. However, there are significant gaps in our knowledge of human prenatal exposure to these synthetic chemicals. In this study, a set of eight SPAs and four major transformation products (TPs) were systematically analyzed in matched samples of maternal plasma, cord plasma, and placenta from a population of pregnant women. Five of the eight target SPAs and all four target TPs were frequently detected in the maternal-placental-fetal unit, indicating prenatal exposure to SPAs and the transfer of SPAs across the placenta. In the three matrices, 2,6-di-tert-butyl-hydroxytoluene (BHT), 2,4-di-tert-butylphenol (DBP), and 2,2'-methylenebis(4-methyl-6-tert-butylphenol) (AO 2246) were identified as the most abundant SPAs, while 2,6-di-tert-butyl-1,4-benzoquinone (BHT-Q) and 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadienone (BHT-quinol) were identified as the predominant TPs of BHT. In the maternal plasma, concentrations of both BHT-Q and BHT-quinol were significantly correlated with BHT (p < 0.001), suggesting that the two TPs mainly originated from the biotransformation of BHT itself in pregnant women. The transplacental transfer efficiencies (TTEs) of the SPAs and TPs were structure-dependent and generally less than 1. Significantly higher TTEs for four target TPs than their parent BHT were identified. To our knowledge, this study provides the first evidence that SPAs and TPs transfer across the placenta in pregnant women.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hidroxitolueno Butilado / Antioxidantes Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País como asunto: Asia Idioma: En Año: 2019 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hidroxitolueno Butilado / Antioxidantes Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País como asunto: Asia Idioma: En Año: 2019 Tipo del documento: Article