Longitudinal Analysis of Pulmonary Function in Survivors of Congenital Diaphragmatic Hernia.
J Pediatr
; 216: 158-164.e2, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31704056
ABSTRACT
OBJECTIVE:
To analyze longitudinal trends of pulmonary function testing in patients with congenital diaphragmatic hernia (CDH) followed in our multidisciplinary clinic. STUDYDESIGN:
This was a retrospective cohort study of CDH patients born between 1991 and 2013. A linear mixed effects model was fitted to estimate the trends of percent predicted forced expiratory volume in 1 second (FEV1pp), percent predicted forced vital capacity (FVCpp), and FEV1/FVC over time.RESULTS:
Of 268 patients with CDH who survived to discharge, 119 had at least 1 pulmonary function test study. The FEV1pp (P < .001), FVCpp (P = .017), and FEV1/FVC (P = .001) decreased with age. Compared with defect size A/B, those with defect size C/D had lower FEV1pp by an average of 11.5% (95% CI, 2.9%-20.1%; P = .010). A history of oxygen use at initial hospital discharge also correlated with decreased FEV1pp by an average of 8.0% (95% CI, 1.2%-15.0%; P = .023).CONCLUSIONS:
In a select cohort of CDH survivors, average pulmonary function declines with age relative to expected population normative values. Those with severe CDH represent a population at risk for worsening pulmonary function test measurements who may benefit from recognition and monitoring for complications.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Capacidad Vital
/
Volumen Espiratorio Forzado
/
Hernias Diafragmáticas Congénitas
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
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Male
/
Newborn
Idioma:
En
Año:
2020
Tipo del documento:
Article