The in vitro dental plaque inhibitory properties of a series of N-[1-alkyl-4(1H)-pyridinylidene]alkylamines.
J Med Chem
; 31(10): 2024-7, 1988 Oct.
Article
en En
| MEDLINE
| ID: mdl-3172139
ABSTRACT
A series of novel N-[1-alkyl-4(1H)-pyridinylidene]alkylamine hydrohalides has been prepared and evaluated as inhibitors of dental plaque formation, in vitro. Several members of the series exhibited potency ca. 9-fold greater than that of chlorhexidine vs Streptococcus sobrinus 6715-13. The di-n-octyl analogue, 11 (pirtenidine), was found to be highly efficacious against several other oral plaque-forming microorganisms and is presently undergoing preclinical evaluation.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Streptococcus
/
Actinomyces
/
Placa Dental
/
Aminopiridinas
/
Antibacterianos
Límite:
Humans
Idioma:
En
Año:
1988
Tipo del documento:
Article