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Shear Wave Elastography Can Differentiate between Radiation-Responsive and Non-responsive Pancreatic Tumors: An ex Vivo Study with Murine Models.
Wang, Hexuan; Mills, Bradley; Mislati, Reem; Ahmed, Rifat; Gerber, Scott A; Linehan, David; Doyley, Marvin M.
  • Wang H; Department of Electrical & Computer Engineering, University of Rochester, Rochester, New York, USA.
  • Mills B; Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
  • Mislati R; Department of Electrical & Computer Engineering, University of Rochester, Rochester, New York, USA.
  • Ahmed R; Department of Electrical & Computer Engineering, University of Rochester, Rochester, New York, USA.
  • Gerber SA; Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
  • Linehan D; Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
  • Doyley MM; Department of Electrical & Computer Engineering, University of Rochester, Rochester, New York, USA. Electronic address: m.doyley@rochester.edu.
Ultrasound Med Biol ; 46(2): 393-404, 2020 02.
Article en En | MEDLINE | ID: mdl-31727378
ABSTRACT
Neither contrast-enhanced computed tomography nor magnetic resonance imaging can monitor changes in the pancreatic ductal adenocarcinoma microenvironment during therapy. We hypothesized that shear wave elastography could overcome this limitation. To test this hypothesis, we measured the shear modulus of two groups of murine pancreatic tumors (KCKO, n = 30; PAN02, n = 30) treated with stereotactic body radiation therapy (SBRT). The mean shear modulus of KCKO tumors was 7.651 kPa higher than that of PAN02 tumors (p < 0.001). SBRT reduced the shear modulus in KCKO tumors by 8.914 kPa (p < 0.001). No significant difference in the shear modulus of SBRT-treated PAN02 tumors was observed. Additionally, necrotic and collagen densities were reduced only in the SBRT-treated KCKO tumors. Shear modulus was dependent on collagen distribution and histological texture parameters (i.e., entropy and fractional dimension). Shear wave elastography imaging differentiates between SBRT-responsive (KCKO) and non-responsive (PAN02) tumors.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Diagnóstico por Imagen de Elasticidad Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Diagnóstico por Imagen de Elasticidad Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article