The impact of hemolysis on stability of <i>N</i>-desethyloxybutynin in human plasma.

Miao, Zhixin; Tan, Melvin; Wells, Edward; Unger, Steve

The impact of hemolysis on stability of N-desethyloxybutynin in human plasma.

Miao, Zhixin; Tan, Melvin; Wells, Edward; Unger, Steve.

Miao Z; Worldwide Clinical Trials, Early Phase Services, Bioanalytical Sciences, Austin, TX 78754, USA.
Tan M; Worldwide Clinical Trials, Early Phase Services, Bioanalytical Sciences, Austin, TX 78754, USA.
Wells E; Worldwide Clinical Trials, Early Phase Services, Bioanalytical Sciences, Austin, TX 78754, USA.
Unger S; Worldwide Clinical Trials, Early Phase Services, Bioanalytical Sciences, Austin, TX 78754, USA.

Bioanalysis ; 11(23): 2133-2144, 2019 Dec.

Article en En | MEDLINE | ID: mdl-31729241

Asunto(s)

Hemólisis; Ácidos Mandélicos/sangre; Ácidos Mandélicos/química; Cromatografía Liquida; Estabilidad de Medicamentos; Humanos; Ácidos Mandélicos/aislamiento & purificación; Estructura Molecular; Espectrometría de Masas en Tándem

Palabras clave

LCMS-MS; N-desethyloxybutynin; bioanalytical; chiral separation; heme-mediated oxidation; hemolysis; method development; oxybutynin; stability; validation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hemólisis / Ácidos Mandélicos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hemólisis / Ácidos Mandélicos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article