Cleistocaltones A and B, Antiviral Phloroglucinol-Terpenoid Adducts from Cleistocalyx operculatus.
Org Lett
; 21(23): 9579-9583, 2019 12 06.
Article
en En
| MEDLINE
| ID: mdl-31755722
ABSTRACT
Two novel phloroglucinol-terpenoid adducts (1 and 2), featuring a rare 2,2,4-trimethyl-cinnamyl-ß-triketone unit, were isolated from the buds of Cleistocalyx operculatus. Their structures with absolute configurations were established by spectroscopic analyses, single-crystal X-ray diffraction, and quantum chemical calculations. Structurally, compound 1 represents a new carbon skeleton possessing a densely functionalized tricyclo[11.3.1.03;8]heptadecane bridged ring system with an unusual bridgehead enol. Compounds 1 and 2 exhibited significant in vitro antiviral activities against respiratory syncytial virus (RSV).
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
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Floroglucinol
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Virus Sincitiales Respiratorios
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Terpenos
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Syzygium
Límite:
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article