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Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis.
Oliveira, Pedro H; Ribis, John W; Garrett, Elizabeth M; Trzilova, Dominika; Kim, Alex; Sekulovic, Ognjen; Mead, Edward A; Pak, Theodore; Zhu, Shijia; Deikus, Gintaras; Touchon, Marie; Lewis-Sandari, Martha; Beckford, Colleen; Zeitouni, Nathalie E; Altman, Deena R; Webster, Elizabeth; Oussenko, Irina; Bunyavanich, Supinda; Aggarwal, Aneel K; Bashir, Ali; Patel, Gopi; Wallach, Frances; Hamula, Camille; Huprikar, Shirish; Schadt, Eric E; Sebra, Robert; van Bakel, Harm; Kasarskis, Andrew; Tamayo, Rita; Shen, Aimee; Fang, Gang.
  • Oliveira PH; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Ribis JW; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
  • Garrett EM; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
  • Trzilova D; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
  • Kim A; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Sekulovic O; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
  • Mead EA; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Pak T; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Zhu S; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Deikus G; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Touchon M; Microbial Evolutionary Genomics, Institut Pasteur, Paris, France.
  • Lewis-Sandari M; CNRS, UMR3525, Paris, France.
  • Beckford C; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Zeitouni NE; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Altman DR; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Webster E; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Oussenko I; Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY, USA.
  • Bunyavanich S; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Aggarwal AK; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Bashir A; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Patel G; Department of Pharmacological Sciences and Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, USA.
  • Wallach F; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Hamula C; Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY, USA.
  • Huprikar S; Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY, USA.
  • Schadt EE; Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY, USA.
  • Sebra R; Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY, USA.
  • van Bakel H; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Kasarskis A; Sema4, Stamford, CT, USA.
  • Tamayo R; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Shen A; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
  • Fang G; Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA.
Nat Microbiol ; 5(1): 166-180, 2020 01.
Article en En | MEDLINE | ID: mdl-31768029
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Metilasas de Modificación del ADN / Clostridioides difficile / Epigénesis Genética Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Metilasas de Modificación del ADN / Clostridioides difficile / Epigénesis Genética Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article