Serum lipidome analysis of healthy beagle dogs receiving different diets.
Metabolomics
; 16(1): 1, 2019 12 03.
Article
en En
| MEDLINE
| ID: mdl-31797205
ABSTRACT
INTRODUCTION:
Food and dietary ingredients have significant effects on metabolism and health.OBJECTIVE:
To evaluate whether and how different diets affected the serum lipidomic profile of dogs.METHODS:
Sixteen healthy beagles were fed a commercial dry diet for 3 months (control diet). After an overnight fasting period, a blood sample was taken for serum lipidomic profile analysis, and each dog was then randomly assigned to one of two groups. Group 1 was fed a commercial diet (Diet 1) and group 2 was fed a self-made, balanced diet supplemented with linseed oil and salmon oil (Diet 2) for 3 months. After an overnight fasting period, a blood sample was taken from each dog. Serum cholesterol and triacylglycerol analyses were performed and the serum lipidomic profiles were analyzed using targeted liquid chromatography-mass spectrometry.RESULTS:
Dogs fed the supplemented self-made diet (Diet 2) had significantly higher omega-3 fatty acid-containing lipids species and significantly lower saturated and mono- and di-unsaturated lipid species. Concentrations of sphingosine 1-phosphate species S1P d161 and S1P d171 were significantly increased after feeding Diet 2.CONCLUSION:
This study found that different diets had significant effects on the dog's serum lipidomic profile. Therefore, in studies that include lipidomic analyses, diet should be included as a confounding factor.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dieta
/
Lípidos
Límite:
Animals
Idioma:
En
Año:
2019
Tipo del documento:
Article