Pembrolizumab Interferes with the Differentiation of Human FOXP3<sup>+</sup>-Induced T Regulatory Cells, but Not with FOXP3 Stability, through Activation of mTOR.

Sasidharan Nair, Varun; Toor, Salman M; Taouk, Ghina; Pfister, Gerald; Ouararhni, Khalid; Alajez, Nehad M; Elkord, Eyad

Pembrolizumab Interferes with the Differentiation of Human FOXP3⁺-Induced T Regulatory Cells, but Not with FOXP3 Stability, through Activation of mTOR.

Sasidharan Nair, Varun; Toor, Salman M; Taouk, Ghina; Pfister, Gerald; Ouararhni, Khalid; Alajez, Nehad M; Elkord, Eyad.

Sasidharan Nair V; Cancer Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Toor SM; Cancer Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Taouk G; Cancer Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Pfister G; Flow Cytometry Core, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar; and.
Ouararhni K; Cancer Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Alajez NM; Cancer Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Elkord E; Cancer Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar; eelkord@hbku.edu.qa eyad.elkord@manchester.ac.uk.

J Immunol ; 204(1): 199-211, 2020 01 01.

Article en En | MEDLINE | ID: mdl-31801817

Asunto(s)

Anticuerpos Monoclonales Humanizados/farmacología; Antineoplásicos Inmunológicos/farmacología; Factores de Transcripción Forkhead/antagonistas & inhibidores; Linfocitos T Reguladores/efectos de los fármacos; Serina-Treonina Quinasas TOR/inmunología; Diferenciación Celular/efectos de los fármacos; Diferenciación Celular/inmunología; Desmetilación/efectos de los fármacos; Factores de Transcripción Forkhead/inmunología; Voluntarios Sanos; Humanos; Estabilidad Proteica/efectos de los fármacos; Linfocitos T Reguladores/inmunología; Regulación hacia Arriba/efectos de los fármacos

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos T Reguladores / Factores de Transcripción Forkhead / Serina-Treonina Quinasas TOR / Anticuerpos Monoclonales Humanizados / Antineoplásicos Inmunológicos Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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