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PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Wiede, Florian; Lu, Kun-Hui; Du, Xin; Liang, Shuwei; Hochheiser, Katharina; Dodd, Garron T; Goh, Pei K; Kearney, Conor; Meyran, Deborah; Beavis, Paul A; Henderson, Melissa A; Park, Simone L; Waithman, Jason; Zhang, Sheng; Zhang, Zhong-Yin; Oliaro, Jane; Gebhardt, Thomas; Darcy, Phillip K; Tiganis, Tony.
  • Wiede F; Monash Biomedicine Discovery Institute, Monash University, Clayton, Vic., Australia.
  • Lu KH; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia.
  • Du X; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
  • Liang S; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
  • Hochheiser K; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
  • Dodd GT; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
  • Goh PK; Monash Biomedicine Discovery Institute, Monash University, Clayton, Vic., Australia.
  • Kearney C; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia.
  • Meyran D; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
  • Beavis PA; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
  • Henderson MA; Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Vic., Australia.
  • Park SL; Peter Doherty Institute for Infection and Immunity, Melbourne, Vic., Australia.
  • Waithman J; Monash Biomedicine Discovery Institute, Monash University, Clayton, Vic., Australia.
  • Zhang S; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia.
  • Zhang ZY; Monash Biomedicine Discovery Institute, Monash University, Clayton, Vic., Australia.
  • Oliaro J; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia.
  • Gebhardt T; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
  • Darcy PK; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
  • Tiganis T; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
EMBO J ; 39(2): e103637, 2020 01 15.
Article en En | MEDLINE | ID: mdl-31803974
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Activación de Linfocitos / Receptores de Antígenos de Linfocitos T / Inmunoterapia Adoptiva / Receptor ErbB-2 / Linfocitos T CD8-positivos / Proteína Tirosina Fosfatasa no Receptora Tipo 2 / Neoplasias Límite: Animals / Female / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Activación de Linfocitos / Receptores de Antígenos de Linfocitos T / Inmunoterapia Adoptiva / Receptor ErbB-2 / Linfocitos T CD8-positivos / Proteína Tirosina Fosfatasa no Receptora Tipo 2 / Neoplasias Límite: Animals / Female / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article